MULTI-LAYERED SUPPORT FOR NATURAL HEALING
Placentally-derived human amniotic membrane (AM) is a potent source of pro-healing growth factors and anti-inflammatory cytokines and has successfully been used in regenerative medicine for over a century. Early users of AM for wounds and post-surgical applications noted how the membrane seemed to disappear and integrate with the patient’s own tissue without a host reaction. This apparent immune neutrality is a result of mechanisms that suppress and modulate the immune system.
The use of AM was initially limited due to storage challenges associated with use of the fresh tissue. Modern processing methods – including dehydration – have delivered options that have longer shelf lives, can be stored at ambient temperatures, and can be terminally sterilized. In recent decades, advances in our understanding of placental tissues and improved processing abilities have resulted in the creation of dehydrated combined amniotic/chorionic membrane (DHACM) products.
DHACM is now widely used where clinicians believe a thicker covering, richer in pro-healing factors, is needed. Post-surgical, trauma, burn, and complex wound applications for DHACM have been well-documented in the literature, and new applications continue to be explored.
The Combined Amniotic and Chorionic Membranes
The combination of amnion and chorion is thicker and higher in tensile strength than allografts containing amnion alone. It is also richer and more varied in growth factors as well thanks to the higher quantity of growth factors present in the chorion layer.